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Impact of MSH2 mutations on mutator phenotype. Wild-type or MSH2Δ cells expressing an empty or MSH2-containing plasmid were selected on caspofungin. Frequency data are mean ± standard deviation (s.d.) from three independent experiments; representative images are shown. P-values determined by student's t-test. A P < 0.05 (two-tailed) is considered statistically significant.
