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. 2016 Dec 23;7:626. doi: 10.3389/fimmu.2016.00626

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Copyright © 2016 Sanmarco, Visconti, Eberhardt, Ramello, Ponce, Spitale, Vozza, Bernardi, Gea, Minguez and Aoki.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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CD8+ T lymphocytes from chagasic patients present high tyrosine nitration. (A) Percentage of nitrated (NT) leukocytes, lymphocytes, and T cells from seropositive patients (n = 6) and seronegative donors (n = 6). (B) Representative dot plot of tyrosine nitration on cytotoxic T-cell surface and percentage of NT+CD3+CD8+ and NT+CD3+CD8− lymphocytes from chagasic patients (n = 6) and non-chagasic donors (n = 6). (C) Percentage of NT+CD3+CD8+ and NT+CD3+CD8− and mean fluorescence intensity of NT in CD3+CD8+ and CD3+CD8− cells from chagasic patients (n = 5) (*p < 0.05, **p < 0.01, and ***p < 0.001). (D) Frequency of naïve, central memory, effector memory (EM), and effector memory RA gated in NT+ or NT− in CD8+ cells from chagasic patients (n = 4) (naïve NT+ vs. naïve NT−, p < 0.0001; EM NT+ vs. EM NT−, p < 0.0001).