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. 2016 Dec 23;7:626. doi: 10.3389/fimmu.2016.00626

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Copyright © 2016 Sanmarco, Visconti, Eberhardt, Ramello, Ponce, Spitale, Vozza, Bernardi, Gea, Minguez and Aoki.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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IL-6 prevents nitration, increases survival of CD3+CD8+ cells, and decreases IL-1β levels after infection. (A) Percentage of NT+CD3+CD8+ cells in infected peripheral blood mononuclear cells (PBMCs) from non-chagasic (n = 5) donors after 48 h of stimulation with IL-6 (Trypanosoma cruzi + IL-6) or αIL-6 (T. cruzi + αIL-6) or medium alone (T. cruzi). (B) Percentage of viable CD3+CD8+ cells infected with T. cruzi (T. cruzi) or infected and stimulated with IL-6 (T. cruzi + IL-6). (C) IL-1β levels and (D) nitric oxide levels in culture supernatants of infected PBMCs after 48 h of stimulation with IL-6 (T. cruzi + IL-6) or αIL-6 (T. cruzi + αIL-6) or medium alone (T. cruzi) (*p < 0.05 and **p < 0.01).