Table 4.
The number of direct and indirect targets for ABI3 and FUS3, and the number of targets that overlap with GeneMANIA associations.
| Regulator | Targets | Cluster 1 | Cluster 2 | Cluster 3 | Cluster 4 |
|---|---|---|---|---|---|
| ABI3 | Direct in known | 0 | 2 | 0 | N/A |
| Indirect in known | 0 | 0 | 0 | N/A | |
| Direct in predict | 2 | 2 | 18 | N/A | |
| Indirect in predict | 12 | 28 | 1 | N/A | |
| Overlap with GeneMANIA | 2 | 5 | 0 | N/A | |
| FUS3 | Direct in known | 9 | 16 | 15 | 4 |
| Indirect in known | 46 | 88 | 74 | 20 | |
| Direct in predict | 40 | 37 | 36 | 16 | |
| Indirect in predict | 427 | 485 | 325 | 121 | |
| Overlap with GeneMANIA | 3 | 7 | 8 | 4 | |
| LEC1 | Overlap with GeneMANIA | 30 | 6 | 2 | N/A |
The direct and indirect targets were obtained from FIMO. LEC1 does not have known binding site in the CIS-BP database, so only ABI3 and FUS3 binding sites were studied. For each regulator, the table shows the number of targets that have the binding sites in known and predicted connections, respectively.