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. 2016 Jun 21;25(15):3303–3320. doi: 10.1093/hmg/ddw179

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© The Author 2016. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — Mecp2^ZFN/y and Mecp2^ZFN/+rats display altered body and brain weights throughout development. (A) Representative example of early malocclusion in a PND ∼28 Mecp2^ZFN/y rat. (B) Mecp2^ZFN/y body weight does not significantly differ from WT body weight throughout development. (PND 21 WT n = 13 Mecp2^ZFN/y n = 11; PND 28 WT n = 12 Mecp2^ZFN/y n = 10; PND 35 WT n = 7 Mecp2^ZFN/y n = 8; PND 42 WT n = 7 Mecp2^ZFN/y n = 8; PND 50 WT n = 13 Mecp2^ZFN/y n = 11; PND 57 WT n = 11 Mecp2^ZFN/y n = 9; PND 64 WT n = 3 Mecp2^ZFN/y n = 4) (C–D) Mecp2^ZFN/+ females are significantly heavier than WTs beginning at postnatal day 60 and continuing through 18 months of age (PND 21 WT n = 21 Mecp2^ZFN/+ n = 25; PND 60–90 WT n = 23 Mecp2^ZFN/+ n = 22; 6 mo WT n = 21 Mecp2^ZFN/+ n = 25; 9 mo WT n = 14 Mecp2^ZFN/+ n = 14; 12 mo WT n = 12 Mecp2^ZFN/+ n = 13; 15 mo WT n = 13 Mecp2^ZFN/+ n = 13; 18 mo WT n = 5 Mecp2^ZFN/+ n = 5). (E) Mecp2^ZFN/y males display significantly decreased brain weight beginning at postnatal day 14 and continuing throughout development. (PND 7 WT n = 5 Mecp2^ZFN/y n = 7; PND 14 WT n = 5 Mecp2^ZFN/y n = 6; PND 21 WT n = 6 Mecp2^ZFN/y n = 6; PND 28–35 WT n = 6 Mecp2^ZFN/y n = 9; PND 47–55 WT n = 9 Mecp2^ZFN/y n = 10; PND 60–80 WT n = 6 Mecp2^ZFN/y n = 5). (F) Mecp2^ZFN/+ females demonstrate significantly decreased brain weight beginning at postnatal day 21 and continuing through 18 months of age. (PND 7 WT n = 4 Mecp2^ZFN/+ n = 7; PND 21 WT n = 5 Mecp2^ZFN/+ n = 3; PND 60–90 WT n = 5 Mecp2^ZFN/+ n = 7; 15 mo WT n = 5 Mecp2^ZFN/+ n = 6; 18 mo WT n = 8 Mecp2^ZFN/+ n = 7). Data are presented as mean ± SE, with asterisks representing significant genotype differences (*P < 0.05, **P < 0.01, ***P < 0.00 1).