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. 2016 Jun 21;25(15):3303–3320. doi: 10.1093/hmg/ddw179

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© The Author 2016. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — Mecp2^ZFN/y and Mecp2^ZFN/+rats display diminished overall wellness and decreased survival. (A) Mecp2^ZFN/y males and (B) Mecp2^ZFN/+ females display increased overall symptom scores relative to WTs throughout development (Males: PND 21–28 WT n = 43 Mecp2^ZFN/y n = 46; PND 35–42 WT n = 23 Mecp2^ZFN/y n = 25; PND 49–55 WT n = 19 Mecp2^ZFN/y n = 17; PND 60+ WT n = 5 Mecp2^ZFN/y n = 7; Females: PND 21–28 WT n = 10 Mecp2^ZFN/+ n = 16; 6 mo WT n = 15 Mecp2^ZFN/+ n = 15; 9 mo WT n = 7 Mecp2^ZFN/+ n = 12). (C) Representative photograph of hindlimb clasping in an adult Mecp2^ZFN/y rat. (D) A Kaplan–Meier survival curve demonstrates that half of Mecp2^ZFN/y males have died by PND ∼55 (WT n = 11 Mecp2^ZFN/y n = 7). Data are presented as mean ± SE, with asterisks representing significant differences (*P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001).