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. 2016 Jun 21;25(15):3303–3320. doi: 10.1093/hmg/ddw179

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© The Author 2016. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 6. — Mecp2^ZFN/y males display motor abnormalities upon Catwalk^TM testing as early as PND 21. (A–B) Mecp2^ZFN/y males cross the runway slower (A) and with a greater number of steps (B) than WTs. (C) Mecp2^ZFN/y males show differences in 3-paw support type at PND 21–28 and PND 50+. (D–E) Right hind swing speed was significantly decreased in Mecp2^ZFN/y males at PND 21–28, and right front and right hind swing speed (D), as well as right front and right hind stride length (E) were significantly decreased at PND 50+. (F) No significant differences were seen in regularity of step pattern between Mecp2^ZFN/y males and WTs. (G) Representative image of footsteps of WT (top) and Mecp2^ZFN/y male (bottom) rats as they cross the Catwalk^TM at PND 50+; R/L F/H = right/left front/hind, AB = abdomen. (PND 21–28 WT n = 10 Mecp2^ZFN/y n = 10; PND 50+ WT n = 12 Mecp2^ZFN/y n = 14). Data are presented as mean ± SE, with asterisks representing significant differences (*P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001).