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. 2016 Jun 21;25(15):3303–3320. doi: 10.1093/hmg/ddw179

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© The Author 2016. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 8. — Mecp2^ZFN/y males display breathing abnormalities consistent with RTT. (A–B) Representative raw data plethysmography traces illustrate (A) eupnic breathing and (B) spontaneous apneic events in WT (top tracings) and Mecp2^ZFN/y (bottom tracings) juvenile males (PND 21–28). Summary data show that juvenile and adult (PND 40+) Mecp2^ZFN/y rats hypoventilate (C) but with no change in TV (F), MV (G), or respiratory irregularity (H) (PND 21–28 WT n = 8, Mecp2^ZFN/y n = 11; PND 40+ WT n = 6, Mecp2^ZFN/y n = 7). Consistent with reduced respiratory frequency, juvenile Mecp2^ZFN/y rats also showed an increase in Ti (D) and Te (E). Data are represented as mean ± SEM, with asterisks representing significant differences (*P < 0.05, **P < 0.01, ***P < 0.001). ∨ designates sigh-like augmented breaths; # identifies apneic events.