Figure 1.

Spanish family with Meniere’s disease with a novel variant in the PRKCB gene. (A) Pedigree of a family presenting AD FMD with three affected men in two generations. Symbols in the pedigree represent: complete MD phenotype (full black square), numbers at the left of the symbol indicate the age of onset; incomplete phenotype (partial black square or circle, upper-left black: vestibular phenotype; lower-right black: cochlear phenotype). Abbreviations: M, Migraine; MA, Migraine with aura; MO, Migraine without aura. (B) Air-conduction audiograms showing a severe sensorineural hearing loss starting at low frequencies in affected individuals at several ages (age symbols shown below the chart); upper X axis represents frequencies in Hz, and Y axis represents hearing level (HL) in dB. (C) Genomic sequence at PRKCB gene (chr16:23999898G > T) with the novel variant (M) segregating hearing loss (indicated in red).