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. 2016 Jul 4;25(16):3515–3523. doi: 10.1093/hmg/ddw194

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© The Author 2016. Published by Oxford University Press. This work is written by US Government employees and is in the public domain in the United States.

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Figure 5. — Inhibition of CX3CR1 restores the responsiveness of Lrrk2–null microglia to LPS stimulation. (A, B) Representative images show GFP signals at the dorsal striatum of Lrrk2^+/+/Cx3cr1^GFP/+ and Lrrk2^–/–/Cx3cr1^GFP/+ (A), as well as Lrrk2^+/+/Cx3cr1^GFP/GFP and Lrrk2^–/–/Cx3cr1^GFP/GFP mice. Scale bars, 50 μm. (C, D) Bar graphs depict the measurements of fractal dimension (C) and area (D) of Lrrk2^+/+/Cx3cr1^GFP/+, Lrrk2^–/–/Cx3cr1^GFP/+, Lrrk2^+/+/Cx3cr1^GFP/GFP, Lrrk2^–/–/Cx3cr1^GFP/GFP microglia. Values represent means ± SEM. Significant differences between the groups are expressed as follows: **P<0.01; ***P<0.001. One-way ANOVA followed by Newman-Keuls multiple comparison tests. N = 4 per group.