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. 2016 Jul 4;25(16):3564–3577. doi: 10.1093/hmg/ddw202

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© The Author 2016. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 8. — Larynx histology and aerophagia in EDA pathway deleted mice A–D larynx mid-sagittal plane. (A) The epiglottis (e) of a 24-week-old FVB mouse has submucosal glands (smg) but these are absent in Edar^dlJ/dlJ and Eda^Ta mice. (B) The epiglottis of 14-week-old Edar^dlJ/dlJ mouse lacks glands and has a submucosal lymphoid follicle (lf). There is exudate (ex) and foreign body (fb) in the proximal trachea. (C,D) Two 25-week-old mice Eda^Ta mice. (C) One Eda^Ta mouse has neutrophil (nl) infiltration of the epiglottis epithelium. (D) a higher magnification image of a submucosal lymphoid follicle (lf) in a second Eda^Ta mouse. (E,F) Soft palate mid-sagittal plane. (E) The soft palate of a 24-week-old FVB mouse has submucosal gland comprising mucous cells (smg) that empty via ducts (arrow head) into the oral cavity (oc); nasopharynx (nd) is lined by ciliated epithelium (ce). (F) The soft palate of a 14-week-old Edar^dlJ/dlJ mouse lacks submucosal glands and this region is occupied by adipose tissue (adp); the nasopharynx is lined by squamous epithelium (se). (G,H) Trachea mid-sagittal plane. (G) The proximal trachea of a 14-week-old Edar^dlJ/+mouse has submucosal glands (smg); (H) these glands are absent in a 25-week-old Eda^Ta mouse. (I) Post mortem appearance of an 18-week-old Eda^Ta mouse with aerophagia that has an air filled stomach, small intestines and caecum. (J,K) small intestine. (J) Duodenum of this Eda^Ta mouse has a normal submucosal Brunner’s gland (brg) and villi (v); (K) the jejunum has an empty lumen. Scale bars: 250 µm (A,B,E–H,J,K); 100 µm (C,D).