Fig. 3. Bioactivity profiling and categorization of petroleum substances in ToxPi. Point-of-departure values derived from sixteen distinct assays or assay parameters were integrated for quantitative bioactivity profiling of 21 petroleum substances in ToxPi (a). The plot reflects a global ranking of petroleum substances according to their cumulative ToxPi score, i.e. each data point represents the sum of individual assay scores shown in the respective bioactivity profiles. Potential bioactivity-based correlations were analyzed using the hclust function in r (b). [VHGO = vacuum & hydrotreated gas oils; SRGO = straight run gas oils; OGO = other gas oils; HFO = heavy fuel oils; RAE = residual aromatic extracts].
