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. 2016 Dec 23;6:39738. doi: 10.1038/srep39738

Figure 7. Efavirenz increases BBB permeability and stroke tissue injury.

Figure 7

(A) Quantification of BBB permeability. Mice were treated for 30 days with either vehicle or NNRTIs as described in the Material and Methods. Translocation of sodium fluorescein (NaF) from plasma into the brain parenchyma was used as the indicator of BBB integrity. Data are mean ± SEM, expressed as fold change compared to vehicle, n = 5 per group. To analyze infarct volume, mice were either mock or EcoHIV/NDK infected and treated as in (A). Brains were stained with TTC 24 h after a 60 min occlusion of the middle cerebral artery occlusion (MCAO). (B) Representative images of infarct areas in brain slices from NNRTI-treated mock-infected mice. Infarct areas are highlighted and indicated by arrows. (C) Quantification of total infarct volume from all animal groups. Data are mean ± SEM, n = 4–7 animals per group. *p < 0.05 vs. Vehicle; **p < 0.01 vs. Vehicle.