Table 1. Top 10 diseases in every class of disease-causing mechanisms, α, and their relative comorbidity risks , ranked by the significance of its overlap with the phenotypic disease layer, .

rank	genetic, α = G
1	F25, Schizo-affective disorders	2.4	<10−4
2	F20, Schizophrenia	2.4	<10−4
3	M19, Osteoarthritis (unspecified)	2.9	<10−4
4	N04, Nephrotic syndrome	2.2	<10−4
5	J41, Simple, mucopurulent chronic bronchitis	2.1	<10−3
6	J42, Chronic bronchitis (unspecified)	2.0	<10−3
7	M15, Polyosteoarthritis	2.6	<10−3
8	N03, Chronic nephritic syndrome	2.3	<10−3
9	F22, Delusional disorders	2.6	<10−3
10	M18, Osteoarthritis (first carpometacarpal joint)	2.5	<10−3
	pathway-based, α = P
1	F32, Major depressive disorder, single episode	1.1	<10−3
2	F33, Major depressive disorder, recurrent	0.81	0.002
3	M85, Disorders of bone density and structure	1.8	0.003
4	G40, Epilepsy and recurrent seizures	0.65	0.003
5	E66, Overweight and obesity	0.83	0.006
6	E85, Amyloidosis	0.58	0.009
7	G25, Other extrapyramidal and movement disorders	0.66	0.010
8	H90, Conductive and sensorineural hearing loss	0.56	0.010
9	M21, Other acquired deformities of limbs	1.3	0.010
10	C90, Multiple myeloma, plasma cell neoplasms	0.90	0.011
	toxicogenomic, α = T
1	I71, Aortic aneurysm and dissection	0.75	0.002
2	L21, Seborrheic dermatitis	0.65	0.002
3	L24, Irritant contact dermatitis	0.99	0.002
4	K52, Gastroenteritis and colitis	0.64	0.002
5	N03, Chronic nephritic syndrome	1.7	0.004
6	L20, Atopic dermatitis	1.2	0.004
7	L28, Lichen simplex chronicus and prurigo	0.69	0.006
8	L30, Unspecified dermatitis	0.58	0.006
9	I89, Noninfective disorders of lymphatic vessels and nodes	0.84	0.008
10	G91, Hydrocephalus	0.96	0.009