Table 3. Sensitivity, specificity, positive predictive value, negative predictive value, positive likelihood ratio, negative likelihood ratio and Youden index comparing various thresholds of HbA1c with the ADA criteria for diabetic ketosis in the subgroup of patients with previously diagnosed T2DM (n = 345).
| HbA1c Thresholds | Sensitivity (%) | Specificity (%) | PPV (%) | NPV (%) | +LR | −LR | Youden index |
|---|---|---|---|---|---|---|---|
| 8.3% (67 mmol/mol) | 89.63 (83.94, 93.51) | 57.00 (49.62, 63.90) | 65.33 (58.90, 71.25) | 85.83 (78.39, 91.06) | 2.08 (1.75, 2.48) | 0.18 (0.11, 0.29) | 0.466 |
| 8.4% (68 mmol/mol) | 88.41 (82.54, 92.53) | 58.00 (50.73, 64.96) | 65.61 (59.12, 71.56) | 84.68 (77.22, 90.05) | 2.11 (1.76, 2.52) | 0.20 (0.13, 0.31) | 0.464 |
| 8.5% (69 mmol/mol) | 87.80 (81.84, 92.04) | 60.00 (52.95, 67.07) | 66.67 (60.13, 72.62) | 84.50 (77.19, 89.81) | 2.21 (1.83, 2.66) | 0.20 (0.13, 0.31) | 0.478 |
| 8.6% (70 mmol/mol) | 86.59 (80.46, 91.04) | 62.00 (54.62, 68.64) | 67.30 (60.70, 73.28) | 83.58 (76.32, 88.97) | 2.27 (1.87, 2.76) | 0.22 (0.15, 0.33) | 0.486 |
| 8.7% (72 mmol/mol) | 84.76 (78.41, 89.51) | 62.00 (55.18, 69.16) | 67.15 (60.48, 73.19) | 81.88 (74.57, 87.47) | 2.26 (1.85, 2.75) | 0.24 (0.17, 0.36) | 0.468 |
| 8.8% (73 mmol/mol) | 81.10 (74.38, 86.39) | 62.00 (55.18, 69.16) | 67.17 (60.35, 73.34) | 78.91 (71.58, 84.77) | 2.26 (1.83, 2.78) | 0.30 (0.21, 0.41) | 0.431 |
| 8.9% (74 mmol/mol) | 79.88 (73.05, 85.33) | 66.00 (58.56, 72.28) | 67.88 (60.99, 74.07) | 78.29 (71.05, 84.14) | 2.33 (1.88, 2.89) | 0.31 (0.22, 0.42) | 0.459 |
Values in parentheses are 95% confidence intervals.
PG: admission plasma glucose. PPV: positive predictive value. NPV: negative predictive value. +LR: positive likelihood ratio. −LR: negative likelihood ratio.