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. 2016 Dec 23;6:39862. doi: 10.1038/srep39862

Table 3. Univariate and multivariate Cox proportional hazard regression analyses of overall survival.

Factor Univariate analysis
 Multivariate analysis
HR(95%CI) P HR(95%CI) P
Gender   0.417    
 Female Reference      
 Male 1.213 (0.761–1.934)      
Age/year   0.479    
 <18 Reference      
 ≥18 0.850 (0.542–1.333)      
Tumor site   0.022   0.061
 Extremities Reference   Reference  
 Non-extremities 2.058 (1.110–3.814)   1.907 (0.971–3.746)  
Enneking’s surgical staging   0.000   0.509
 I/II Reference   Reference  
 III 2.751 (1.559–4.855)   1.228 (0.668–2.255)  
Karnofsky performance status score   0.262    
 ≥80 Reference      
 ≤70 1.561 (0.717–3.399)      
Neoadjuvant chemotherapy   0.311    
 No Reference      
 Yes 0.756 (0.441–1.298)      
Pathological fracture   0.258    
 No Reference      
 Yes 0.618 (0.268–1.423)      
Local recurrence   0.162    
 No Reference      
 Yes 1.449 (0.861–2.439)      
Metastasis   0.000   0.000
 No Reference   Reference  
 Yes 12.751 (6.642–24.479)   10.407 (5.265–20.570)  
NLR   0.000   0.009
 0 Reference   Reference  
 1 2.645 (1.682–4.160)   2.097 (1.202–3.658)  
PLR   0.030   0.186
 0 Reference   Reference  
 1 1.746 (1.056–2.887)   0.676 (0.379–1.207)  
LMR   0.020   0.796
 0 Reference   Reference  
 1 0.559 (0.342–0.912)   0.927 (0.524–1.641)  
GPS   0.000   0.009
 0 Reference   Reference  
 1/2 5.596 (2.501–5.170)   2.250 (1.222–4.145)  
CRP   0.000   0.709
 0 Reference   Reference  
 1 3.133 (1.874–5.239)   1.166 (0.521–2.610)  
NPS   0.803    
 0 Reference      
 1/2 1.101 (0.515–2.358)      

GPS = Glasgow prognostic score; CRP = the C-reactive protein; NLR = neutrophil-lymphocyte ratio; PLR = platelet-lymphocyte ratio; LMR = lymphocyte-monocyte ratio; NPS = neutrophil platelet score; HR = hazard ratios; CI = confidence interval.