Table 4.

Multivariable Associations of Reproductive Factors with Cognitive Composite Scores^a

	Global Composite (n=755)		Verbal Memory (n=748)		Executive Functions (n=739)
	Estimate (SE)	p-value	Estimate (SE)	p-value	Estimate (SE)	p-value
Age (years)	−0.03 (0.01)	0.006	−0.05 (0.02)	<0.001	−0.12 (0.02)	<0.001
Race or Ethnicity
White non-Hispanic	Ref	<0.001b	Ref	<0.001b	Ref	<0.001b
Black non-Hispanic	−0.83 (0.21)		−0.74 (0.36)		−1.91 (0.42)
Hispanic	−1.00 (0.18)		−1.33 (0.31)		−2.99 (0.36)
Asian or Pacific Islander	−0.85 (0.20)		−1.40 (0.36)		−1.69 (0.41)
Other	−1.02 (0.45)		−1.76 (0.79)		−1.42 (0.90)
Education (years)	0.15 (0.03)	<0.001	0.15 (0.05)	0.003	0.40 (0.06)	<0.001
Income (annual)
Less than 50,000	Ref		Ref
50,000 – 89.9000	0.41 (0.15)	0.008	0.76 (0.27)	0.006	0.67 (0.31)	0.03
More then 90,0000	0.71 (0.15)	<0.001	1.26 (0.27)	<0.001	1.25 (0.31)	<0.001
Not reported	−0.04 (0.24)	0.88	0.11 (0.42)	0.79	0.05 (0.48)	0.92
Age at Menarche
<13 years	Ref		Ref		Ref
≥13 years	−0.23 (0.11)	0.05	−0.27 (0.20)	0.19	−0.28 (0.23)	0.23
Age at Last Pregnancy
≤35 years	Ref		Ref		Ref
>35 years	0.25 (0.14)	0.07	0.54 (0.25)	0.03	−0.08 (0.28)	0.77
Never Pregnant	0.21 (0.20)	0.29	0.53 (0.35)	0.13	0.26 (0.41)	0.52
Duration of Hormonal Contraception
None	Ref	0.04b	Ref	0.007b	Ref	0.06b
<5 years	0.59 (0.17)	<0.001	0.93 (0.30)	0.002	0.65 (0.34)	0.06
5–10 years	0.44 (0.17)	0.01	0.73 (0.30)	0.02	0.41 (0.35)	0.24
>10 years	0.51 (0.18)	0.005	1.07 (0.32)	<0.001	0.89 (0.37)	0.02
Reproductive Period (years)	0.03 (0.01)	0.04	0.03 (0.02)	0.11	0.05 (0.02)	0.04
Number of Full-Term Pregnancies
1 full-term	Ref		Ref		Ref
2 full-term	0.17 (0.17)	0.33	0.42 (0.30)	0.17	0.45 (0.35)	0.19
>2 full-term	0.24 (0.17)	0.17	0.45 (0.31)	0.15	0.42 (0.36)	0.23
No full-term	0.61 (0.22)	0.005	1.00 (0.39)	0.01	0.50 (0.45)	0.26

^aAdjusted for age at cognitive testing, education, and race/ethnicity

^bGlobal p-value (race/ethnicity) or p-value for trend (duration of hormonal contraceptive use)