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. Author manuscript; available in PMC: 2016 Dec 23.
Published in final edited form as: J Am Chem Soc. 2012 Dec 27;135(2):669–682. doi: 10.1021/ja306028q

Figure 1.

Figure 1

Schematic diagram of MLL1 in histone 3 lysine 4 (H3K4) methylation and in leukemogenesis. (a) Wild-type MLL1 complex methylates H3K4, and the core complex is required for robust catalytic activity. (b) MLL1 fusion proteins cooperate with wild-type MLL1 complex to activate MLL1 target genes, leading to leukemogenesis. MLL1N, N-terminus of MLL1; MLL1C, C-terminus of MLL1.