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. Author manuscript; available in PMC: 2016 Dec 23.
Published in final edited form as: J Am Chem Soc. 2012 Dec 27;135(2):669–682. doi: 10.1021/ja306028q

Figure 3.

Figure 3

Crystal structure of WDR5/MM-102 complex. WDR5 is colored in green and MM-102 is colored in yellow. (a) Electron density (2Fo – Fc) map, contoured to 1δ, for MM-102. (b) Comparison of MM-101 and MM-102 in WDR5 complexes. In WDR5/MM-101 complex, WDR5 is colored in salmon and MM-101 is in cyan. (c) Intramolecular hydrogen bonds in MM-102 are shown in magenta dotted lines. (d) Interface between MM-102 (yellow) and WDR5 (green). MM-102 and WDR5 pack across an extensive interface, involving both hydrophobic packing and hydrogen bonds (magenta dotted lines). Intramolecular hydrogen bonds and water molecules are shown as blue dotted lines and orange spheres, respectively.