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. Author manuscript; available in PMC: 2016 Dec 23.
Published in final edited form as: Microbiol Spectr. 2014 Jun;2(3):10.1128/microbiolspec.MGM2-0012-2013. doi: 10.1128/microbiolspec.MGM2-0012-2013

Table 1.

P-ATPases in M. tuberculosis

Gene name Group Predicted substrate(s) Comments References
ctpA/Rv0092 1B1 Cu+/Ag+ N-term CxxC; C-term MxxSS
ctpB/Rv0103c 1B1 Cu+/Ag+ N-term CxxC; C-term MxxSS
ctpC/Rv3270 1B? Zn2+; possibly others Putative metallochaperone Rv3269; M. tuberculosis mutant sensitive to zinc (53)
ctpD/Rv1469 1B4 Co2+ C-term HEGxT; M. smegmatis homologue transports Co2+ (84)
ctpE/ 2A-like Unknown PEGL(P/V) motif found in calcium-transporting P-ATPases, such as SERCA
ctpF/ 2A Ca2+ PEGL(P/V) & Tm6-LWxNxxxd motifs found in calcium-transporting P-ATPases, such as SERCA
ctpG/Rv1992c 1B? Possibly Cd2+/Pb2+ & others Putative metallochaperone Rv1993c; repressed by Rv1994c/CmtR, unless Cd2+ or Pb2+ are present (81)
ctpH/ 2A-like Unknown Large N-term membrane spanning domain; Tm6-PEGl(P/V) motif found in calcium-transporting P-ATPases, such as SERCA
ctpI/ 2A-like Unknown Large N-term membrane spanning domain; Tm6-PEGL(P/V) motif found in calcium-transporting P-ATPases, such as SERCA
ctpJ/Rv3743c 1B4 Co2+ C-term HEGxT; repressed by Rv3744/NmtR, unless Ni2+ or Co2+ are present (51)
ctpV/Rv0969 1B1 Cu+ C-term MxxSS; M. tuberculosis mutant sensitive to copper; putative metallochaperone Rv0968; in operon with copper-responsive regulator csoR/Rv0967 (53, 56)
kdpB/Rv1030 1A K+ Homologous to many KdpB potassium transporters