Table 2.

Association of quartiles of lipoprotein(a) or apolipoprotein(a) size and cryptogenic stroke in non-Hispanic whites.

Models	Quartile 1		Quartile 2		Quartile 3		Quartile 4
	OR (95% CI)	p value	OR (95% CI)	p value	OR (95% CI)	p value	OR (95% CI)	p value
Lipoprotein(a), molecular-weight dependenta (n=391)
Model 1	Referent	NA	0.54(0.28, 1.07)	0.077	1.04(0.57, 1.88)	0.902	1.63(0.93, 2.84)	0.087
Model 2	Referent	NA	0.57(0.26, 1.25)	0.159	1.31(0.67, 2.55)	0.437	1.81(0.95, 3.47)	0.073
Model 3d	Referent	NA	0.58(0.24, 1.38)	0.218	1.46(0.69, 3.07)	0.325	2.02(1.01, 4.04)	0.048
Lipoprotein(a), molecular-weight independentb (n=398)
Model 1	Referent	NA	0.61(0.30, 1.24)	0.176	1.23(0.65, 2.32)	0.533	1.59(0.87, 2.91)	0.133
Model 2	Referent	NA	0.78(0.35, 1.79)	0.563	1.49(0.72, 3.06)	0.281	2.10(1.04, 4.27)	0.040
Model 3d	Referent	NA	0.70(0.28, 1.77)	0.454	1.54(0.68, 3.51)	0.299	2.34(1.10, 4.98)	0.027
Apolipoprotein(a), KIV-2 repeatsc (n=354)
Model 1	0.85(0.46, 1.56)	0.593	0.83(0.43, 1.58)	0.572	0.97(0.53, 1.78)	0.933	Referent	NA
Model 2	0.85(0.43, 1.67)	0.630	0.73(0.35, 1.51)	0.394	1.02(0.52, 2.00)	0.958	Referent	NA
Model 3e	0.78(0.37, 1.66)	0.520	0.98(0.45, 2.11)	0.952	1.06(0.51, 2.22)	0.881	Referent	NA

^a25^th, 50^th and 75^th percentile cutpoints are 6, 12.3 and 32.7 mg/dl, respectively. Multiply by 0.0357 to convert to μmol/L.

^b25th, 50th and 75^th percentile cutpoints are 3.1, 11.5 and 51.6 nmol/L, respectively.

^c25^th, 50^th and 75^th percentile cutpoints are 21, 22.5 and 27 KIV-2 repeats, respectively.

Model 1: adjusted for age and sex.

Model 2: adjusted for age, sex, hypertension, diabetes, dyslipidemia, current smoker, migraine with aura, family history of premature cardiovascular disease, C-reactive protein.

Model 3: adjusted for covariates in Model 2 plus ^dnumber of kringle IV type 2 repeats or ^elog of molecular-weight independent Lp(a).

CI: confidence interval, KIV-2: Kringle IV Type 2, NA: not applicable, OR: odds ratio.