Table 1.
Testing P-values of association between ASD and CNVs in each chromosome
| Chromosome | #CNVs | CKAT | Fisher’s exact | CCRET |
|---|---|---|---|---|
| chr1 | 175 | 8.2e-2 | 3.1e-1 | 3.5e-2 |
| chr2 | 45 | 1.7e-4 (*) | 4.3e-4 (*) | 2.4e-2 |
| chr3 | 49 | 0 (*) | 1.8e-14 (*) | 1 |
| chr4 | 112 | 8.2e-1 | 8.3e-1 | 8.6e-1 |
| chr5 | 242 | 2.3e-2 | 2.3e-2 | 9.4e-2 |
| chr6 | 17 | 1.2e-4 (*) | 3.4e-5 (*) | 1 |
| chr7 | 25 | 1.2e-4 (*) | 1.4e-4 (*) | 3.1e-2 |
| chr8 | 3 | 0.1e-1 | 2.5e-1 | 1 |
| chr9 | 13 | 7.7e-1 | 7.8e-1 | 2.1e-1 |
| chr10 | 130 | 4.7e-1 | 3.3e-1 | 4.2e-1 |
| chr11 | 257 | 8.8e-1 | 8.0e-1 | 5.6e-1 |
| chr12 | 3 | 2.7e-1 | 6.1e-1 | 1.1e-1 |
| chr13 | 5 | 7.4e-1 | 1 | 3.2e-1 |
| chr14 | 2 | 1.8e-1 | 5.0e-1 | 1 |
| chr15 | 919 | 5.4e-1 | 2.6e-1 | 1 |
| chr16 | 140 | 3.7e-1 | 8.4e-1 | 6.0e-2 |
| chr17 | 27 | 2.3e-3 | 4.5e-3 | 2.4e-1 |
| chr18 | 6 | 1 | 1 | 1 |
| chr19 | 17 | 3.2e-2 | 8.0e-2 | 3.5e-2 |
| chr20 | 3 | 1.3e-1 | 2.5e-1 | 3.0e-1 |
| chr21 | 0 | NA | NA | NA |
| chr22 | 166 | 0 (*) | 1.3e-21 (*) | 3.0e-1 |
| chrX | 2 | 1.4e-2 | 2.2e-1 | 1 |
| chrY | 1 | 2.9e-1 | 4.7e-1 | 1 |
# denotes the number of CNVs on that chromosome, 1.0e-2 stands for , and (*) denotes significance after Bonferroni adjustment at family-wise error rate (FWER) of 0.05.