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of three gene-specific variances estimators, limma, limmaR and our proposed estimator (vash) in simulation scenarios, which simulate the last four GTEx tissue pair comparisons (‘Brain-Anteriorcingulatecortex (BA24) vs Cervix-Endocervix’, ‘Brain-CerebellarHemisphere vs Stomach’, ‘Fallopian Tube vs Skin-Not Sun Exposed (Suprapubic)’ and ‘Adrenal Gland vs Stomach’) in Figure 3
