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. 2016 Jun 3;25(14):2997–3010. doi: 10.1093/hmg/ddw153

Figure 5.

Figure 5.

NVP-BGJ398 improves in vivo condyle growth of Fgfr3Y367C/+ mice. (A) Representative 3D reconstructions of 16-day-old WT and Fgfr3Y367C/+ mice treated with DMSO or NVP-BGJ398 for 15 days since P01 (scale bar = 1 mm). (B) Measurement of the mandible body and the condyle length and width of WT and Fgfr3Y367C/+ mice treated with DMSO or NVP-BGJ398 (n ≥ 6 individuals for each genotype and treatment). Total length of the mandible and the length of the condyle were measured . The length of the body was calculated as the total length minus the condyle. (C and D) PCA of the Procrustes shape coordinates of the landmarks measured on mandibles of WT and Fgfr3Y367C/+ mice treated with DMSO or NVP-BGJ398 and corresponding superimposition (n ≥ 6 individuals for each genotype and treatment). Data shown as mean with SD; ***P < 0.005.