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. 2016 Mar 2;25(12):2600–2611. doi: 10.1093/hmg/ddw072

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© The Author 2016. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 10. — Proportion of the regional heritability that can be explained by the top SNP association. The variance explained by a SNP (R²) divided by the regional heritability estimate for DNAm sites with a regional heritability estimate significant at P < 0.05. Only the most significant SNP within the local region was considered. In 4.2% of cases the SNP explained more variance in the DNAm level than did the region.