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. 2016 Apr 7;25(12):2378–2392. doi: 10.1093/hmg/ddw105

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© The Author 2016. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 1. — Overexpression of TDP-43 affects the axonal transport of vesicles but not mitochondria. Live imaging analysis of (A) mitochondrial transport or (B) NPY containing vesicles in Drosophila motor axons overexpressing either Drosophila TBPH or human TDP-43 variants. Mitochondria are marked by UAS-mito.GFP and vesicles by UAS-NPY.GFP, driven by CCAP-GAL4. The number in brackets indicates the number of movies analyzed. Representative kymographs of the indicated genotypes are shown. Control genotype; (A) CCAP-GAL4/+; UAS-mito.GFP/UAS-lacZ, (B) CCAP-GAL4/+; UAS-NPY.GFP/UAS-lacZ. Statistical analysis was performed using one-way ANOVA with Sidak’s multiple comparison test: **P < 0.01, ****P < 0.0001. Charts show mean ± SEM.