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. 2016 Apr 7;25(12):2378–2392. doi: 10.1093/hmg/ddw105

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© The Author 2016. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 8. — Overexpression of caz can rescue behavioral but not transport phenotypes in TBPH mutants. TBPH mutants were analyzed alone or in combination with transgenic expression of caz variants and assayed for (A) eclosion, (B) larval crawling and (C) adult climbing ability. (D) Live imaging analysis of mitochondrial transport in Drosophila motor axons. The number in brackets indicates the number of movies analyzed and representative kymographs of the indicated genotypes are shown. N (animals) ≥ 100 (A), ≥20 (B), ≥50 (C). Control genotypes; (A, B, C) D42-GAL4/UAS-lacZ, (D) CCAP-GAL4/+; UAS-mito.GFP/+. The mutant genotype carries heterozygous D42-GAL4 in the background. Data in (C) are normalized to control. Statistical analysis was performed using one-way ANOVA with Sidak’s multiple comparison test, except (C) which was analyzed by Kruskal–Wallis non-parametric test with Dunn’s correction: *P < 0.05, **P < 0.01, ****P < 0.0001. Charts show mean ± SEM.