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Opa3L122P mice show compromised vertebral strength. Geometry (A) trabecular architecture (B) and mechanical strength (C) were quantified in L5 lumbar vertebrae from 30-day-old male WT (n = 5) and homozygous Opa3L122P littermate mice (n = 5). Data presented are mean ± SEM, with statistical analysis performed by unpaired Student’s t test; a P < 0.05; aa P <0.01, aaa P <0.001 versus WT males.
