Figure 1.

Identification and characterization of DhMLs. (A) Scatterplot of normalized genome-wide 5hmC reads within each 10-kb bin. Reads were normalized to coverage. Color of each point shows the number of bins with the given number of reads. (B) Characteristics of DhMLs from each dataset identified with diffReps. (C) Annotation of DhMLs by Homer shows enrichment and depletion of DhMLs by genomic feature. (D) Genes containing DhMLs were identified by Homer annotation for each dataset, and 325 genes were identified in both datasets. (E) The number of gene ontology terms assigned to significantly enriched gene ontology term groups for DhML-containing genes identified by ClueGO. Asterisks indicate that the displayed term is the most significant gene ontology term in a related group of gene ontology terms. (F) Gene ontology network of shared genes. For simplicity, only the most significant gene ontology term for each group is shown.