Figure 3.

Summary of CMRO₂ data from wild type (white) and R6/2 (hatched) cortex (left column) and striatum (right column). (A, B) DNP injection significantly increased CMRO₂ in both regions of all mice, but the increase in R6/2 (hatched) was less than in wild type (white) mice. (C, D) Oligomycin injection decreased the CMRO₂ in striatum and cortex of both R6/2 (hatched) and wild type (white) mice. No differences were observed between R6/2 and WT mice in either region. (E, F) No differences in CMRO₂ were observed between regions or genotype when saline was injected prior to the second ¹⁷O₂ inhalation. Data are mean + SD. N = 10–11 for A, B. N = 3–5 for E, F. P values appear above lines indicating significant comparisons.