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. Author manuscript; available in PMC: 2017 Jan 1.
Published in final edited form as: Lancet Neurol. 2017 Jan;16(1):55–65. doi: 10.1016/S1474-4422(16)30291-5

Figure 1. Diagnostic accuracy of the “one-year rule” to detect advanced SYN or AD neuropathology.

Figure 1

A) Distribution of neuropathological AD groups among PDD and DLB clinical phenotypes in relation to the one year motor-dementia interval (MDI) rule (dashed line). B) ROC curve analysis testing the diagnostic accuracy of the MDI to distinguish neocortical stage of synucleinopathy. AUC (0·67, p=0·05), sensitivity of 80%, and specificity of 42% using the one-year rule (intersection of dashed lines). C) ROC curve analysis testing the diagnostic accuracy of the MDI to distinguish SYN+AD pathology. AUC (0·72, p=0·0004), sensitivity of 76%, and specificity of 55% using the one-year rule (intersection of dashed lines).