Table 1.
Neuropathological data in Lewy body spectrum disorders stratified by burden of Alzheimer’s disease pathology
| High-Level AD N=63 |
Intermediate-Level AD N=45 |
Low-Level AD N=56 |
No-AD N=49 |
p-Value | |
|---|---|---|---|---|---|
| Post-mortem Interval (hrs) (IQR) | N=46 10 (5,17·5) |
N=38 10·5 (5·25,16) |
N=50 9 (4,15·5) |
N=44 8 (5·5, 14) |
0·8 |
| Brain weight (g) (SD) | N=46 1274·0 (175·3) ‡,† |
N=38 1318·6 (122·4) |
N=50 1286·4 (140·9) |
N=44 1335·6 (165·6) |
0·04 |
| Braak/CERAD Stage Frequency | B3/C2=16 B3/C3=47 |
B2/C2=17 B2/C3=25 B3/C1=3 |
B1/C1=7 B1/C2=16 B1/C3=17 B2/C0=11 B2/C1=5 |
B0/C0=8 B1/C0=41 |
- |
| Lewy body Stage Frequency | BP=0 TL= 8 (12·7%) ND= 55 (87·3%) |
BP= 0 TL= 3 (6·7%) ND= 42 (93·3%) |
BP = 1 (1·8%) TL= 10 (17·9%) ND= 45 (80·4%) |
BP= 3 (7·1%) TL= 13 (26·5%) ND= 33 (67·3%) |
0·02# |
| Cerebral NFT Score (IQR) | N=61 2·0 (1·4,2·5) †‡* |
N=44 1·1 (0·7, 1.5) ‡* |
N=55 0·5 (0·3,0·8) ‡ |
N=42 0·3 (0·1, 0·5) |
<0·0001 |
| Cerebral NP Score (IQR) | N=60 2·1 (2·0, 2·7) *‡ |
N=45 2·2 (1·6, 2·7) ‡* |
N=55 1·3 (0·5, 2·1) ‡ |
N=46 0 (0,0) |
<0·0001 |
| Cerebral SYN Score (IQR) | N=59 2·1 (1·4, 2·6) *‡ |
N=45 1·9 (1·6, 2·5) ‡* |
N=54 1·6 (1·1, 2·0) ‡ |
N=44 1·2 (0·8, 1·8) |
<0·0001 |
| NFT Basal Ganglia Score (IQR) | N=46 1 (1,1·3) †*‡ |
N=39 0 (0,1) ‡ |
N=48 0 (0,0·8) |
N=42 0 (0,0) |
<0·0001 |
| NP Basal Ganglia Score (IQR) | N=46 0 (0,1) ‡ |
N=39 0 (0,2) ‡ |
N=48 0 (0,1) ‡ |
N=47 0 (0,0) |
<0·0001 |
| SYN Basal Ganglia Score (IQR) | N=48 1 (1,3) *‡ |
N=40 1 (0,2) |
N=48 1 (0,2) |
N=40 1 (0,2) |
0·03 |
| CAA Score (IQR) | N=44 1 (0,2) †*‡ |
N=39 0 (0,1) ‡ |
N=48 0 (0,1) ‡ |
N=45 0 (0,0) |
<0·0001 |
| CA2/3 LN Score (IQR) | N=45 2 (1,3) |
N=38 2 (1,3) |
N=48 2 (0·25, 2) |
N=43 2 (1,3) |
0·6 |
| Hippocampal TDP-43 Frequency | 11/29 (38%) | 8/34 (24%) | 9/44 (21%) | 7/43 (16%) | 0·2 |
| HpScl Frequency | 6/61 (10%) | 2/44 (5%) | 2/51 (4%) | 8/48 (17%) | 0·1 |
| AGD Frequency | 1/54 (2%) | 1/41 (3%) | 0/51 (0%) | 1/46 (2%) | 0·8 |
| CVD Frequency | 11/60 (18%) | 6/43 (14%) | 9/53 (17%) | 9/48 (19%) | 0·9 |
Normally-distributed variables are presented as mean (SD), non-parametric ordinal scores are presented as median (IQR) and categorical variables presented as frequency (%). LBSD=Lewy body spectrum disorders, hrs= hours, B=Braak Tau stage (NIA/AA criteria), C=CERAD NP score, BP= brainstem predominant LBD stage, TL= transitional/limbic LBD stage, ND= neocortical/diffuse LBD stage, CAA= Cerebral amyloid angiopathy, CA2/3 LN= dystrophic Lewy neurites in CA2/3 hippocampus, HpScl= Hippocampal sclerosis, AGD= argyrophilic grain disease, CVD= cerebrovascular disease. P-values correspond to 4 group comparison. Symbols below depict values from individual group comparisons:
p<0·05 compared to intermediate AD group
p<0·05 compared to low AD group
p<0·05 compared to pure LBD group
p<0·05 for linear trend association in categorical variables