Table 3.
Clinical characteristics of Lewy body spectrum disorders stratified by burden of Alzheimer’s disease pathology
| High-Level AD N=63 |
Intermediate-Level AD N=45 |
Low-Level AD N=56 |
No-AD N=49 |
p-Value | |
|---|---|---|---|---|---|
| Clinical Phenotype Frequency | PDD=17 (37%) DLB=46 (73%) |
PDD=22 (49%) DLB=23 (51%) |
PDD=37 (66%) DLB=19 (34%) |
PDD=39 (80%) DLB=10 (20%) |
<0·0001# |
| Sex | |||||
| Women | 25 (40%) | 12 (27%) | 15 (27%) | 9 (18%) | |
| Men | 38 (60%) | 33 (73%) | 41 (73%) | 40(82%) | 0·09 |
| Age at Motor Onset (years) (SD) | N=50 73.1 (7·9) ‡*† |
N=42 69·6 (8·0) ‡ |
N=52 66·6 (10·2) ‡ |
N=49 59·6 (11·1) |
<0·0001 |
| Age at Dementia Onset (years) (IQR) | N=61 76·0 (69,81) ‡ |
N=43 73·0 (67, 79) |
N=54 74·5 (70, 80) ‡ |
N=48 70·5 (60·5, 76) |
0·005 |
| Motor-Dementia Interval (years) (SD) | N=48 1·1 (6·1) ‡* |
N=40 2·8 (6·8) ‡* |
N=50 7·1 (7·7) |
N=48 8·6 (8·2) |
<0·0001 |
| Age at Death (years) (IQR) | N=63 81 (75, 86) ‡ |
N=45 79·1 (73·5, 84)‡ |
N=56 79 (73·3, 82·7)‡ |
N=49 75·0 (66·5, 80) |
0·001 |
| Dementia Death Interval (years) (SD) | N=61 5 (3,7) |
N=43 5 (3, 7) |
N=53 3 (2, 6·5) |
N=48 5.5 (3,7) |
0·2 |
| Survival (years) (SD) | N=61 8·0 (5·2) ‡*† |
N=45 10·0 (5·6) ‡ |
N=56 11·5 (6·9) ‡ |
N=49 14·9 (6·8) |
<0·0001 |
Normally-distributed variables are presented as mean (SD), non-parametric variables are presented as median (IQR) and categorical variables presented as frequency (%). P-values correspond to 4 group comparison. Symbols below depict values from individual group comparisons:
#
p<0·001 for linear trend association in categorical variables
†
p≤0·06 compared to intermediate AD group
*
p≤0·01 compared to low AD group
‡
p≤0·01 compared to pure LBD group