Fig.3.

Efficacy of LBH589 in R6/2 HD mouse model. A-B. Bars: solid black = HD vehicle; light gray = low dose, dark gray = high dose, white = wild-type vehicle-treated. A) Higher dose (30 mg/kg) of LBH589 has a negative effect on body weight and a small negative effect of lower dose (10 mg/kg) was also observed at later stages of 11-12 weeks. B-C) LBH589-treatment does not improve the motor performance or striatal volume of R6/2 HD mice D) Stereological quantification of striatal neuronal cell body volume revealed small but significant reduction in neuronal cell body atrophy with the dose of 10 mg/kg. Error bars represent SEM, n = 9-10; ^**p < 0.01.