Fig.4.

LBH589 rescues HD phenotype in CAG140 KI HD mice A-D. Bars: solid black = KI vehicle; light gray = LBH589 10 mg/kg and dark gray = wild-type vehicle-treated. A) Body weight data showed that LBH589 is well tolerated up to 18 weeks of age however a small negative effect of LBH589 on body weight was observed at later stages of treatment. B) LBH589 treatment ameliorates behavioral deficits in CAG 140 KI mice. Latency to fall was increased by 25, 30 and 36% at 6, 8, and 10 months of age. n = 10– 14 (C-D) Stereological quantification of total striatal volume and neuronal cell body volume. LBH589 treatment improves the total striatal volume of HD mice and rescues the shrinkage of striatal neuronal cell body volume. Data represent mean±SEM, n = 6 for KI mice and 4 for wild-type mice; ^*p < 0.05, ^**p≤0.01; ^***p≤0.001.