Table 4.
Classification of protein intercatome of the AβPP and its catabolites related to fatty-acid metabolism
| UniProt ID | Name(a) | Peptides (95%)(b) | Function |
| O70503 | Estradiol 17-beta-dehydrogenase 12 GN = Hsd17b12 | 2 | Catalyzes the second of the four reactions of the long-chain fatty acids elongation cycle |
| Q9R1J0 | Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating GN = Nsdhl | 1 | Involved in the sequential removal of two C-4 methyl groups in post-squalene cholesterol biosynthesis |
| O35704 | Serine palmitoyltransferase 1 GN = Sptlc1 | 1 | Involved in the pathway sphingolipid metabolism |
| O55137 | Acyl-coenzyme A thioesterase 1 GN = Acot1 | 1 | Catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH) |
| Q8BWT1 | 3-ketoacyl-CoA thiolase, mitochondrial GN = Acaa2 | 1 | Involved in the pathway fatty acid beta oxidation |
| Q8K0C4 | Lanosterol 14-alpha demethylase GN = Cyp51a1 | 1 | Catalyzes C14-demethylation of lanosterol |
| Q8JZN5 | Acyl-CoA dehydrogenase family member 9, mitochondrial GN = Acad9 | 2 | Mitochondrial complex I assembly (By similarity) |
| Q922J9 | Fatty acyl-CoA reductase 1 GN = Far1 | 1 | Catalyzes the reduction of saturated fatty acyl-CoA with chain length C16 or C18 to fatty alcohols |
| Q99JY0 | Trifunctional enzyme subunit beta, mitochondrial GN = Hadhb | 1 | Involved in the pathway fatty acid beta-oxidation |
| Q8BLN5 | Lanosterol synthase GN = Lss | 1 | Catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol |
UniProtID, protein accession number in Swiss-Prot/Trembl. (a)Protein name given by UniProt database. (b)Number of unique peptides matching the protein with a confidence limit of 95%. GN, gene name.