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. Author manuscript; available in PMC: 2017 Dec 20.
Published in final edited form as: Immunity. 2016 Dec 20;45(6):1311–1326. doi: 10.1016/j.immuni.2016.11.008

Figure 1. Deletion of Lxrβ on an ApoE-null background is sufficient to provoke autoimmune disease.

Figure 1

(A) Kidney sections from indicated ages of Apoe−/− and Apoe−/−Lxrβ−/− mice immunostained for IgG, B220, CD3 and CD68. (B) Plasma samples from 8-week-old and 24-week-old Apoe−/− and Apoe−/−Lxrβ−/− mice were analyzed for anti-nuclear antibody (ANA) titers by ELISA. (C) Flow cytometric analysis of CD19+B220+ B cells from lymph node of 8-week-old Apoe−/− and Apoe−/− Lxrβ−/− mice. (D) Percentages of indicated cell populations in lymph node of Apoe−/− and Apoe−/−Lxrβ−/− mice analyzed by flow cytometry. (E) Cell counts of the indicated cell populations in lymph node of ApoE−/− and Apoe−/−Lxrβ−/− mice analyzed by flow cytometry. N=4–6 per group. Statistical analysis was performed with Student’s t test. *p < 0.05, **p < 0.01, NS, not significant. Error bars represent means +/− SEM. See also Figure S1.