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. Author manuscript; available in PMC: 2017 Dec 20.
Published in final edited form as: Immunity. 2016 Dec 20;45(6):1311–1326. doi: 10.1016/j.immuni.2016.11.008

Figure 4. Loss of LXRβ expression in hematopoietic cells promotes the development of autoimmune disease.

Figure 4

Bone marrow cells from Apoe−/− and Apoe−/−Lxrβ−/− mice were transplanted into Apoe−/− mice. Mice were analyzed 12 weeks after the transplantation. (A) Gene expression in from lymph node and spleen of Apoe−/− mice transplanted with bone marrow cells from Apoe−/− or Apoe−/− Lxrβ−/− mice analyzed by real-time PCR. (B) Percentages of indicated cell populations in lymph node and spleen of Apoe−/− mice transplanted with bone marrow cells from Apoe−/− or Apoe−/−Lxrβ−/− mice analyzed by flow cytometry. (C) Plasma Baff concentration in Apoe−/− mice transplanted with bone marrow cells from Apoe−/− or Apoe−/−Lxrβ−/− mice determined by ELISA. N=6 per group. Statistical analysis was performed with Student’s t test. *p < 0.05, **p < 0.01, NS, not significant. Error bars represent means +/− SEM.