Figure 4.

Difference in the mean change from baseline in (A) FEV₁; (B) morning PEF; (C) daily reliever use; and (D) symptom score between B/F and placebo, by disease severity. Vertical lines represent 95% confidence intervals. Moderate COPD was defined as FEV₁ 80%–50% predicted, severe COPD as FEV₁ 50%–30% predicted, and very severe COPD as FEV₁ <30% predicted, according to GOLD 2016 criteria (3-month data set; Calverley et al, Szafranski et al, and CLIMB studies).⁹,¹⁰,¹²

Abbreviations: B/F, budesonide/formoterol; COPD, chronic obstructive pulmonary disease; FEV₁, forced expiratory volume in 1 s; inh, inhalations; mPEF, morning peak expiratory flow rate.