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. 2016 Dec 19;10:35–46. doi: 10.2147/OTT.S112686

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© 2017 Lei et al. This work is published and licensed by Dove Medical Press Limited

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MALAT1 promoted ovarian cancer-cell growth.

Notes: (A) MALAT1 knockdown was achieved by si-MALAT1 and the inhibitory efficiency was verified by real-time PCR. (B, C) MTT assays revealed that knockdown of MALAT1 significantly attenuated the proliferation of both SKOV3 and A2780 cell lines over time, compared with the si-NC group. (D, E) Bromodeoxyuridine assays revealed that knockdown of MALAT1 markedly reduced DNA synthesis of both SKOV3 and A2780 cell lines. Data presented as mean ± standard deviation of three independent experiments. **P<0.01.

Abbreviations: si, small interfering; PCR, polymerase chain reaction; NC, negative control; OD, optical density.