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. Author manuscript; available in PMC: 2016 Dec 23.
Published in final edited form as: Science. 2016 Apr 28;352(6285):600–604. doi: 10.1126/science.aad9417

Fig. 4. Contribution of regulatory variants to complex traits.

Fig. 4

(A) Annotations identified with significant enrichment for GWAS traits by fgwas (23). (B) Annotations identified with significant enrichment for GWAS traits by polyTest (16). (C) Quantile-quantile (Q-Q) plot for multiple sclerosis GWAS suggests that splicing plays an important role in the etiology of multiple sclerosis. (D) Model of the regulatory mechanisms through which common variants affect complex traits.