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. 2016 Nov 19;8(11):2936–2946. doi: 10.18632/aging.101102

Figure 1. Ubiquitin-dependent proteasome protein degradation pathway shown as an interacting network.

Figure 1

Pathway activation features are shown for the averaged pediatric ALL, pediatric AML and adult AML transcriptomes. Up-regulated nodes are shown in green, down-regulated - in purple, color legend is provided at the bottom. Saturation of the color is proportional to logarithm of cancer-to-normal (CNR) expression rate for each node of the pathway.