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. Author manuscript; available in PMC: 2018 Jan 1.
Published in final edited form as: Trends Genet. 2016 Dec 1;33(1):68–80. doi: 10.1016/j.tig.2016.11.003

Figure 1.

Figure 1

The Bateson–Dobzhansky–Muller Model of Hybrid Incompatibility. In the ancestral population, the genotype is AABB. After the two populations are isolated, new mutations arise independently on each lineage as indicated by the asterisks. In one population, A evolves into a, in the other population B evolves into b. In hybrids, negative interactions between the a and b alleles can result in sterility or inviability. The a and b alleles are found together for the first time in hybrids, explaining how this incompatibility could evolve without either lineage experiencing an intermediate state of reduced fitness.