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. Author manuscript; available in PMC: 2017 Dec 22.
Published in final edited form as: Cell Chem Biol. 2016 Nov 17;23(12):1504–1514. doi: 10.1016/j.chembiol.2016.10.009

Figure 2.

Figure 2

A. Alignment of the ammosamide (amm) and lymphostin (lym) biosynthetic gene clusters. Related orphaned gene cluster (xan) from S. xanthophaeus also included. ORFs of high sequence homology are connected with a dotted line. TAR cloning sites for amm are indicated with “X”. Conserved genes are indicated with brackets and tailoring genes are outline in black. B. For ammosamide B and lymphostin, structural features derived from tailoring genes in their respective pathways are highlighted in grey. C. Aligned translated sequences of the short ORFs in amm, lym, and xan pathways. FNLD motif is in bold. Abbreviations: H = hypothetical protein; LD = lantibiotic dehydratase; P = peptidase; O = oxidoreductase; Amt = amido transferase; M = methyl transferase; Hal = halogenase. Pairs of ‡ * ¤ ¥ indicate homologues.