Skip to main content
. Author manuscript; available in PMC: 2017 Dec 22.
Published in final edited form as: Cell Chem Biol. 2016 Nov 23;23(12):1515–1525. doi: 10.1016/j.chembiol.2016.10.012

Figure 3.

Figure 3

Relationships between alpha-Gal responses, survival, and Galectin-3 responses. A) Kaplan-Meier estimate for alpha-Gal-08-specific IgG response at week 40. Eight patients had changes greater than 4.7-fold (red line, median survival=30 months) and 20 patients had changes 4.7-fold or less (blue line, median survival=60 months, Log-rank p = 0.005). B) The magnitude of anti-alpha-Gal-08 response (Log2 scale) is inversely associated with patient survival. Pearson correlation r = −0.42 (p = 0.025). C) Heatmap of anti-alpha-Gal responses and anti-galectin-3 response at both week 40 and week 48. Data for each patient are displayed in rows. Patients are grouped by their responses to galectin-3 (blue: positive response (Y), red: negative response (N), separated by a white line). Columns represent 6 array components from the alpha-Gal antigen family. The magnitude of anti-alpha-Gal response is denoted by different colors: black (no/low response), yellow (medium response) and red (large response). D) Dot plots of anti-alpha-Gal response and anti-galectin-3 response at week 40. The dotted line indicates a cutoff of 4-fold change. p-values were calculated using Mann-Whitney test.