Table 2.
Patient distribution and outcome according to the HCT-CI and HCT-CI/age (n=346).
| MODEL | Patients n (%) |
Cum. Inc. NRM at 100 days (95%CI) |
Cum. Inc. NRM at 1 years (95%CI) |
Cum. Inc. NRM at 3 years (95%CI) |
Probability OS at 1 years (95%CI) |
Probability OS at 3 years (95%CI) |
CRFS at 1 year (95%CI) |
CRFS at 3 year (95%CI) |
|---|---|---|---|---|---|---|---|---|
| HCT-CI | ||||||||
| 0 | 75 (22) | 5.3 (1.7–12.1) | 9.3 (4.1–17.2) | 15.2 (8–24.6) | 82.7 (72–89.5) | 67 (54.8–76.6) | 74.7 (63.2–83) | 58.2 (46.1–68.5) |
| 1–2 | 110 (32) | 4.5 (1.7–9.6) | 11.8 (6.6–18.6) | 16.5 (10.2–24.1) | 82.7 (74.3–88.6) | 69.4 (59.7–77.2) | 74.5 (65.3–81.7) | 65.9 (56.1–74) |
| ≥3 | 161 (47) | 8.7 (5–13.7) | 19.9 (14.1–26.4) | 32.2 (25–39.6) | 68.3 (60.5–74.9) | 48.6 (40.5–56.2) | 61.5 (53.5– 68.5) | 46 (38.1–53.6) |
| HCT-CI/age | ||||||||
| 0 | 15 (4) | 0 | 0 | 7.3 (0.4–29.2) | 93.3 (61.3–99) | 85.6 (53.3–96.2) | 86.7 (56.4–96.5) | 66.7 (37.5–84.6) |
| 1–2 | 122 (35) | 4.9 (2–9.8) | 9.8 (5.4–15.9) | 14.3 (8.7–21.3) | 83.6 (75.8–89.1) | 68.8 (59.6–76.4) | 74.6 (65.9–81.4) | 63.4 (54.1–71.4) |
| 3–4 | 118 (34) | 3.4 (1.1–7.9) | 14.4 (8.8–21.4) | 25 (17.5–33.2) | 77.1 (68.4–83.7) | 56.4 (46.8–65) | 66.9 (57.3–74.4) | 53.5 (44–62.1) |
| ≥5 | 91 (26) | 14.3 (8–22.3) | 25.3 (16.8–34.6) | 36.7 (26.7–46.7) | 61.5 (50.7–70.6) | 45.4 (34.8–55.4) | 59.3 (48.5–68.6) | 43.5 (33.1–53.5) |
| Overall | 346 (100) | 6.6 (4.3–9.6) | 15 (11.5–19) | 23.5 (19.2–28.2) | 76 (71.2–80.2) | 59.2 (53.8–64.3) | 68.5 (63.3–73.1) | 55 (49.5–60.1) |
Abbreviations: Cum. Inc, cumulative incidence; NRM, non-relapse mortality; OS, overall survival; CRFS, chronic graft-versus-host disease-free, relapse-free survival.