Table 1.
Baseline Characteristics for the Entire Cohort (n = 7,284)
| Characteristic | Value |
|---|---|
| Donor characteristics | |
| Donor age, years | 29 (20–44) |
| Donor diabetes | 235 (3.2) |
| Donor smoking history (>20 pack-years ever) | 1,819 (25.2) |
| Donor cocaine use (ever) | 518/5,564 (9.3) |
| Terminal serum creatinine, mg/dL | 0.9 (0.7–1.2) |
| Donor BMI, kg/m2 | 23.8 (21.3–26.8) |
| PO2 on 100% inspired oxygen (n = 5,390) | 455 (383–514) |
| Recipient characteristics | |
| Age, years | 54 (44–60) |
| Age ≥ 60 years | 1,919 (26.4) |
| Female sex | 3,561 (48.9) |
| Race | |
| White | 6,472 (88.9) |
| Black | 490 (6.7) |
| Hispanic | 233 (3.2) |
| Asian | 54 (0.7) |
| Other/unknown | 35 (0.5) |
| Cause of lung failure | |
| Obstructive disease | 4,110 (56.8) |
| Restrictive disease | 1,836 (25.4) |
| CF or immunodeficiency | 1,023 (14.1) |
| Pulmonary vascular disease | 273 (3.8) |
| Comorbidities | |
| Diabetes | 631 (8.8) |
| Hypertension | 1,141 (16) |
| Cerebrovascular disease | 50 (0.7) |
| Creatinine at transplantation, mg/dL | 0.8 (0.7–1.0) |
| BMI at transplantation, kg/m2 | 23.7 (20.2–27.2) |
| Chronic steroid use before transplantation | 3,396/6,831 (49.7) |
| Status before transplantation | |
| Hospitalized | 293 (4) |
| Intensive care unit | 163 (2.2) |
| Requiring life support at transplantationa | 300 (4.1) |
| Ventilator dependent at transplantation | 124 (1.7) |
| Lung allocation score (n = 827) | 36.3 (33.4–42.0) |
| Pulmonary function and hemodynamics | |
| Oxygen requirement, L (n = 6,376) | 2 (2–3) |
| FEV1, % predicted (n = 6,695) | 25 (18–45) |
| FVC, % predicted (n = 6,671) | 49 (38–61) |
| FEV/FVC (n = 6,648) | 0.56 (0.39–0.98) |
| Mean PA pressure, mm Hg (n = 5,002) | 25 (20–30) |
| PVR, Wood units (n = 4,270) | 2.6 (1.8–3.6) |
| Cardiac index, L/min/m2 (n = 4,713) | 2.8 (2.4–3.4) |
| Days on waitlist | 312 (112–656) |
| Transplantation characteristics | |
| Bilateral transplantation | 3,358 (46.1) |
| HLA mismatch level 3+ | 5,655/5,890 (96) |
| Donor/recipient sex mismatch | 2,321 (31.9) |
| Donor/recipient race mismatch | 2,354 (32.3) |
| Donor/recipient CMV mismatch | 1,113/5,194 (21.4) |
| Ischemic time, hours (n = 6,369) | 4.5 (3.4–5.6) |
a
Includes ventilator, extracorporeal membrane oxygenation, intravenous inotropes, intra-aortic balloon pump, or inhaled nitric oxide.
Values are expressed as median (IQR), n (%), or n/N (%).
BMI = body mass index; CF = cystic fibrosis; CMV = cytomegalovirus; FEV1 = forced expiratory volume in 1 second; FVC = forced vital capacity; HLA = human leukocyte antigen; IQR = interquartile range; PA = pulmonary pressure; PO2 = partial pressure of oxygen; PVR = pulmonary vascular resistance.