Table 3.
Surgery-responsive microRNAs with mRNA Targets Related to Insulin Signaling.
| Symbol | Seed | p-value | microRNA Fold Change ± SD |
# Targets in Insulin Signaling |
Targets in Insulin Signaling Pathway |
|---|---|---|---|---|---|
| miR-1227-3p | GUGCCAC | 0.02 | 2.23 ± 0.35 | 2 | PRKC1, SOCS3 |
| miR-4691-5p | UCCUCCA | 0.03 | 1.98 ± 0.09 | 2 | PIK3C3, PRKAG1 |
| miR-219a-5p | GAUUGUC | 0.02 | 1.80 ± 0.19 | 8 | GSK3B, OCRL, PIK3C3G, PPP1R14B, PRKCI, RAPGEF1, RHOQ, SHC1 |
| miR-4728-3p | AUGCUGA | 0.02 | 1.64 ± 0.20 | 2 | EIF4E, MAPK1 |
| miR-103-3p | GCAGCAU | 0.02 | 1.59 ± 0.25 | 8 | CRKL, IRS2, JAK1, PDE3B, PIK3R1, PRKCI, SOS1, SYNJ1 |
| miR-3622a-3p | CACCUGA | 0.04 | 1.54 ± 0.21 | 1 | PIK3R6 |
| miR-4749-3p | GCCCCUC | 0.03 | 1.53 ± 0.31 | 2 | PRKACA, RAPGEF1 |
| miR-125b-5p | CCCUGAG | 0.01 | 1.50 ± 0.28 | 10 | ASIC1, EIF2B2, EIF4EBP1, GRB10, PIK3C2B, PIK3CD, PIK3R5, PPP1CA, RAF1, RHOQ |
| miR-3926 | GGCCAAA | 0.01 | −1.52 ± 0.31 | 1 | PRKAR2B |
| miR-224-5p | AAGUCAC | 0.01 | −1.53 ± 0.12 | 5 | CBL, CRKL, GSK3B, IRS2, PIK3R3 |
| miR-4723-5p | GGGGGAG | 0.01 | −1.58 ± 0.08 | 6 | AKT1, FOXO4, PIK3R2, PRKACA, RRAS, VAMP2 |
| miR-16-5p | AGCAGCA | 0.02 | −1.59 ± 0.11 | 27 | AKT3, CRKL, EIF2B5, EIF4E, FOXO1, GRB10, INSR, IRS1, IRS2, KRAS, LIPE, MAP2L1, MAPK3, MRAS, OCRL, PIK2C3A, PIK3R1, PPP1R11, PRKAR2A, RAF1, RAPGEF1, SGK1, SOS1, SOS2, SYNJ1, TRIP10, TSC1 |
| miR-3690 | CCUGGAC | 0.01 | −1.73 ± 0.08 | 2 | PIK3R5, SCNN1G |
| miR-208a-3p | UAAGACG | 0.01 | −1.82 ± 0.10 | 3 | IRS2, PRKAR1A, SOS2 |
| miR-4716-3p | AGGGGGA | 0.04 | −1.87 ± 0.12 | 3 | AKT2 PRKACA, STXBP4 |
| miR-4525 | GGGGGAU | 0.04 | −1.91 ± 0.07 | 2 | PRKACA, VAMP2 |
| miR-2355-5p | UCCCCAG | 0.02 | −1.93 ± 0.12 | 4 | CBL, FOXO4, PIK3CD, PPP1R3C |
| miR-4782-5p | UCUGGAU | 0.02 | −2.29 ± 0.16 | 1 | GYS1 |
*
microRNAs listed limited to those with ≥ |1.5| fold change from baseline.