Table 4.
microRNAs Correlated to Change in HOMA with >3 Insulin Signaling Targets.
| Symbol | Seed | p- value |
HOMA r |
# Targets in Insulin Signaling |
Targets in Insulin Signaling Pathway |
|---|---|---|---|---|---|
| miR-155-5p | UAAUGCU | 0.021 | 0.88 | 11 | CBL, FOXO3, GSK3B, INPP5D, KRAS, PIK3R1, PRKAR1A, PRKCI, RHOQ, RPTOR, SOS1 |
| miR-503-5p | AGCAGCG | 0.045 | 0.82 | 10 | EIF4E, INSR, MAP2K1, OCRL, PIK3C2A, PIK3R1, PPP1R11, RAF1, SGK1, SLC2A4 |
| miR-199a-5p | CCAGUGU | 0.005 | 0.94 | 7 | CBL, GRB10, GSK3B, PIK3CD, PPP1R12A, SLC2A4, SOS2 |
| miR-539-5p | GAGAAAU | 0.005 | 0.94 | 7 | AKT3, EIF4E, FOXO3, INPP5D, MAPK1, PPP1CB, PRKAG2 |
| miR-874-3p | UGCCCUG | 0.012 | 0.91 | 4 | CRK, GSK3B, INPP5B, PPP1CA |
| miR-4664-5p | GGGGUGC | 0.029 | −0.86 | 4 | ACLY, INPP5D, OCRL, PRKAR2A |
| miR-4747-5p | GGGAAGG | 0.030 | −0.86 | 4 | ASIC1, GRB2, RRAS2, SCNN1A |
| miR-516b-5p | UCUGGAG | 0.038 | 0.84 | 3 | CBL, GYS1, PIK3R5 |
| miR-126-3p | CGUACCG | 0.041 | 0.83 | 4 | CRK, CRKL, IRS1, PIK3R2 |
| miR-122-5p | GGAGUGU | 0.047 | 0.82 | 4 | AKT3, CBL, FOXO3, GYS1 |