Figure 4.

Migration patterns from the two primary neural proliferative zones. A. The Dorsal Proliferative System consists of the ventricular (VZ) and subventricular zones. Radial glial cells in the VZ are a major population of neural progenitor cells; they also extend a cellular process from the VZ to the cortical surface that serves as a kind of scaffold for migrating neurons. The ganglionic eminences (GE) make up the Ventral Proliferative zone. Interneurons (green) migrating into the cerebral wall from the GE interact with radial glia (red) and can exhibit changes in direction of migration after contacting radial glia. Interneurons can use radial glia as a scaffold upon which to migrate as they ascend to the cortical plate (CP) or descend in the direction of the ventricular zone (VZ). Particular orientation and morphological dynamics of migration may be associated with particular subsets of interneurons²³ Creative Commons Attribution 2.5 Generic. B. Most of the projection neurons in the brain are produced in the VZ and an adjacent proliferative region called the SVZ (not shown). Radial glia progenitors produce neurons that then migrate to the neocortex via the radial glial scaffold. Malatesta and Gotz ²⁴.